The biological effect  of an acute LD₅₀ dose of the carpet viper,  Echis coloratus crude venom on Liver Total protein, Triglycerides with   alanine transaminase (ALT), aspartate transaminase, (AST) and gamma glutamyl transferase (GGT), enzyme activity, Kidney creatinine, total protein concentration and Alkaline phosphatase (ALP)  in the liver, abdominal muscles and cerebrum brain were measured.  The effect of the LD₅₀ dose was monitored over a period of seven days, with time interval of 1,3,6,12,24,72 hours. Regarding tissue enzymes activities tested show fluctuation with time, with tendency to regain normal control level after 12 hours. The 12 to 24 hours seems to be crucial for the process of physiological recovery, in spite of the irreversible damage and tissue distraction. It is concluded that the process of physiological adaptation and recovery from the lethal destructive venom effect seems to stabilized after one week, leaving the animal alive with several biochemical altered metabolism and disturbed physiological profile.