The ayurvedic drugs Glymin^®, Hyponidd^®, Madhumerin^®, Mersina^® and Limit^® are administered as anti-diabetic drugs in the Indian system of medicine in which Gymnema sylvestre is a common ingredient. We investigated the antimicrobial properties of the ethanolic extracts of these drugs against common microbes causing diabetes-depended infections using agar-well diffusion method. The zone of inhibition (in the order of high to low) for each drug was: Glymin – S. aureus, S. pyogenes, B. subtilis, Pseudomonas aeruginosa; Limit – B. subtilis, S. pyogenes, S. aureus, Enterococcus faecalis; Mersina – S. aureus, S. pyogenes, B. subtilis, E. faecalis; Madhumerin – S. pyogenes, C. albicans,  S. aureus; and Hyponidd – S. pyogenes. The minimum inhibitory concentration of the drugs against the test microorganisms were in the range of 75 – 200 mg ml^-1 (1.9 – 5.0 mg well^-1). The Gas Chromatograph – Mass Spectrometric analysis of the ethanolic extracts of the drugs revealed the presence of Ar-tumerone and curlone in Madhumerin; palmitic and benzoic acids in Glymin^®; tetradecanoic acid, asarone and caryophyllene in Limit^®; a-citral in Mersina^® and d-elemene in Hyponidd^® to a high percentage similarity with the internal standards of the instrument. To sum up, this study suggests that the components present in the polyherbal formulations (Mersina^®, Glymin^® and Limit^®) would play a vital role in inhibiting diabetes-depended infections thereby reducing the gravity of the disease with the advantage of reducing treatment cost and the quantity of drug consumption.