Ultrasonic scaling and antibiotic therapy are traditional therapeutic method of inflammation around the implant but therapeutic effect is not ideal. In view of maintaining flora balance around the implant and implant long-term solid holdup, this experiment observes impact and clinical effect of lactobacillus metabolite on inflammation around the impact to explore a new kind of ecological drug. This drug have little or no side effect, good curative effect and low recurrence rate, which can be applied for broad groups of people¹. 16 cases of inflammation around the impact were divided into experimental group and control group, 8 cases for each group. Lactobacillus metabolites gargle was offered to experimental group; purified water was offered to control group. Gargle way is 3 times/ day, 20 ml/time, 3 min/ time and for 7 days. Two groups of cases were clinical and microbiological tested before gargle, 3 days, 7 days and 30 days after gargle. Based on clinical and microbiological test of 8 cases of health implant, we observe subgingival flora variation trend and clinical effects of infectors with inflammation around implant. Conclusion: 1. lactobacillus metabolite can improve clinical index of inflammation around the impact including MPLI, GI, MBI and PD. 2. Lactobacillus metabolite has a strong treatment effect on inflammation around the implant and do not have side effect.