Research purpose of this paper is to comprehend clinical distribution and drug-resistance situation of methicillin-resistant staphylococcus aureus. The method is to use automatic microbe instrument Microscan W /A 96 to do strain identification and drug susceptibility test on separated strains. The research found that 312 strains of MRSA were separated in three years, which account for 58.1% of staphylococcus aureus. MRSA is mainly distributed in wound secretion, purulent sputum and prostatic fluid and less come from blood specimens; Endemic area distribution is mainly in intensive care unit, neurosurgery, respiratory medicine, dermatology, burns orthopaedic and orthopaedics. MRSA show high drug resistance of 82.37%~ 100% to most antibiotics besides vancomycin, cotrimoxazole and rifampicin. And its drug resistance towards ampicillin, amoxicillin/acid, cefalotin, cefazolin, tienam, benzylpencilline, penicillin and tetracycline is 100% and 90% towards clindamycin, cefotaxime, clarithromycin and gentamicin.