ISSN: 0973-7510
E-ISSN: 2581-690X
A novel injectable hydrogel for biomedical applications was successfully fabricated by human-like collagen (HLC) and chitosan (CS) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) as cross-linker. The compression strength and crosslinking densities of the hydrogels were characterized by Electronic Universal Testing Machine. The results showed that the HLC and CS were successfully cross-linked through amide bonds and EDC could be a strong backbone in the hydrogel to keep its appearance. The results of the equilibrium swelling ratio and compression module of these hydrogels indicated that the compression moduli of these gels were directly proportional to their crosslinking densities and sol-gel transition was become true at 37°C. Therefore, CS-HLC/b-GP-EDC hydrogels are suitable for biomedical applications such as soft tissue augmentation for their good crosslinking densities.
Hydrogel, Human like collagen, Mechanical strength, Crosslinking densities
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