ISSN: 0973-7510

E-ISSN: 2581-690X

Mohammad Sadegh Hashemzadeh1, Atena Nouhi Tabalvandani2, Nasim Padasht4, Saman Ayoubi3, Roya Ramzanian4, Mansoreh Hoseinzadeh4, Zahra Latifi4, Mahdi Tat1, Mojtaba Sharti1, Maryam Habibpour4, Somaye Arshad4 and Ruhollah Dorostkar1
1Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2Department of Biology, Faculty of Science, University of Urmia, Urmia, Iran.
3Allergy and Asthma Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
4Department of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University (IAU), Lahijan, Iran.
J. Pure Appl. Microbiol., 2016, 10 (1): 345-350
© The Author(s). 2016
Received: 11/11/2015 | Accepted: 20/12/2015 | Published: 31/03/2016

The unknown cases of serological diagnosis of HTLV-1, 2 virus are of the issues in blood transfusion centers. So in this study, we investigated and determined the sero-epidemiological prevalence of HTLV-1 and HTLV-2 among blood donors in Guilan province of Iran. In this experimental study, 200 serum samples of blood donors were evaluated in terms of HTLV-1, 2 viruses by ELISA screening. Repeatability of positive cases was confirmed using Western blot analysis.  In Western blot analysis, the number of 50 persons of the donors was reported as negative and there were significant differences between donors with negative and positive results in terms of age and sex.  Uncertain cases in the serology of HTLV infection are of the problems of blood transfusion centers around the world. The prevalence of unknown cases among blood donors in Guilan province of Iran was determined more than non-endemic areas and lower than endemic regions.


HTLV-1 and 2, Blood donors, Prevalence, ELISA.

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© The Author(s) 2016. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.