The present work describes two new spectrophotometric methods for the determination of phenazopyridine hydrochloride (PPH) in bulk and formulations. The methods are based on the reduction of Fe3+ into Fe2+ by the drug followed by the complex formation of Fe2+ with 1,10 phenanathroline (method A) and 2,2′ bipyridyl (method B) to form red colored chromogen having maximum absorbance at 530nm and 520nm for methods A and B respectively. Beer’s law is obeyed in the range of 2-10 ?g/mL with molar absorptivity of 2.185 × 104 for method A and 2.305 X 104 for method B respectively. The results were favorably compared with those obtained by reference UV spectrophotometric method. The accuracy, precision, and the linearity ranges of the methods have been determined, and they have been validated by analyzing the title drug. No interference was observed from common pharmaceutical adjuvants.These two methods were successfully applied to the pharmaceutical formulations, capsules, tablets.
Sandell’s sensitivity, Phenazopyridine, Beer’s law
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