Methicillin Resistant Staphylococcus aureus (MRSA) is an important hospital pathogen, incidence of Methicillin Resistant Staphylococcus aureus is on rise. The present study was performed to know the incidence of MRSA in chronic, osteomyelitis patients admitted in a tertiary care hospital. The bacteria causing chronic osteomyelitis were isolated using standard laboratory techniques. MRSA was identified using oxacillin (1ug) disc by modified Kirby Bauer disc diffusion method. The antibiotic sensitivity testing of S. aureus isolates was done to other antibiotics also.  The proportion of MSRA among S.aureus isolates was 63.04%. The study shows increasing incidence of MRSA in chronic osteomyelitis as these strains may be hospital acquired or community acquired. All the MRSA were sensitive to Vancomycin. The present study also shows that these MRSA are less sensitive to other antibiotics.