To compare rural and urban setups of Methicillin Sensitive Staphylococcus aureus (MSSA) with socio-economic and behavioral factors and their susceptibility patterns to various antimicrobial agents. A total no. of 13774, 5263 (38.21%) from rural and 8511 (61.79%) from urban pus samples were analysed. Samples with confirmed Staphylococcus aureus were subsequently tested for methicillin sensitivity and cefoxitin disc antibiotic susceptibility pattern was determined. The data was analysed statistically. Isolated rate of Methicillin sensitive Staphylococci aureus (MSSA) 288 (5.47%), (5.24%).ratio of sex was 1:0.77, 1: 0.78 in rural and urban setup. Isolated rate of Methicillin sensitive Staphylococci aureus (MSSA) 288 (5.47%), (5.24%).ratio of sex was 1:0.77, 1: 0.78 in rural and urban setup. Ratio of isolation of MSSA in rural and urban group in various socio economic classes were :Upper I(1.4:1),Upper middle II (1:3.7),Lower middle III(1:2.2),Upper lower IV(1.01:1) and Lower V(1.4:1).Average drug resistance percentage (more than 50%) of MSSA in various socio-economic groups from rural setup was for penicillin 91.77%, erythromycin 77.13%, azithromycin 69.07%, ciprofloxacin 74.63%, gatifloxacin 82.34%, cefuroxime 54.95% and cefoperazone 90.89%. Average drug resistance percentage (more than 50%) of MSSA in various socioeconomic groups from urban setup was penicillin 88.77%, erythromycin 69.57%, ciprofloxacin 55.73%, gatifloxacin 68.16%, cefuroxime 57.04% and cefoperazone 79.24%. In both the groups cloxacillin, azithromycin, amikacin, gentamicin, tetracycline, cephalexin, linezolid, vancomycin and piperacillin+tazo can be used. Average drug resistance to penicillins, erythromycin, ciprofloxacin, gatifloxacin and cefoperazone was more in rural areas when compared to urban areas in all the socioeconomic groups requiring the need for regular surveillance of MSSA infection in rural areas.