ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access

Shailza Shreshtha1, Pradeep Kumar1, Preeti Sharma1 and Rachna Sharma2

1Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad – 201 001, India.
2Department of Biochemistry, TSM Medical College and Hospital, Lucknow – 226 003, India.
J Pure Appl Microbiol, 2019, 13 (1): 133-140 | Article Number: 5506 | © The Author(s). 2019 

Received: 17/01/2019 | Accepted: 01/03/2019 | Published: 28/03/2019

Cytokine release syndrome (CRS) is a life threatening toxicity associated numerous immunotherapeutic techniques involving monoclonal antibodies, bispecific antibodies and adoptive T cell therapies. It is also referred as infusion reaction that results in release of large amount cytokines (Like IL-6, IFN-r, INF) from the target cells. Cytokines when released in excessive amounts into the circulation produces systemic symptoms like nausea, shills, fever, rashes, headache, hypotension, dyspenea etc. Most of the patients present mild to moderate symptoms which can be managed easily but some patients show life threatening symptoms. Studies have shown that immunosuppressive agents like corticosteroids and tocilizumab can reverse the toxicity of CRS, however such immunosuppression may limit the immunotherapeutic efficacy. Therefore specific precautions must be considered in such patients to present exacerbation of the complication. Thus this review is based on the overview of CRS which include etiology, mechanism and management of CRS, so that immunotherapeutic benefits can be maximized with minimum risk of complication.


Cytokine release syndrome, monoclonal antibodies, chimeric antigen receptor modified T- cells, cortiocsteroids, tocilizumab.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.