Identification of a micro RNA (miRNA) based biomarker with multiple gene targets is a major challenge in the era of post genomics and the ability to apply an accurate computational method leads to the initiation of discovering novel miRNAs. In order to identify a miRNA based target interaction among the genes which are associated in the disease pathology of Psoriasis, we obtained a list of Psoriasis related genes from a database for Genome Wide Association Studies (GWAS) and then we went on to identify the network of miRNAs which are significantly related to the GWAS of Psoriasis. Further, we performed an enrichment analysis for identifying a specific miRNA on the basis of statistical tests to predict the miRNA which has the potential to become a biomarker. Finally we have identified the binding of the selected miRNA with the genes which are associated with Psoriasis. At present we have applied the above mentioned protocol for Psoriasis and in future this protocol can also be applied to other diseases.