ISSN: 0973-7510
E-ISSN: 2581-690X
Comparative study of antimicrobial activity of eight antibiotics which are used conventionally for the treatment of diarrhea, i.e. Ampicillin, Ceftriaxone, Doxycycline, Levofloxacin, Norfloxacin, Nalidixic acid, Trimethoprim sulfamethoxazoleand Tetracycline was studied with the use of pathogensisolated and identified from the stool samples collected from various diarrheal patients admitted at various Government and Private hospitals of Akola district. The antimicrobial activity was determined by studying Minimum Inhibitory Concentration (MIC)using Clinical and Laboratory Standard Institute (CLSI) guidelines.The microdilution procedure using 96 wells microdilutionplates was employed. Results revealed Increase in microbial resistance by enteric pathogen against antimicrobials Ampicillin, Nalidixic acid, Tetracycline and Doxycycline with high MIC50 and MIC90 values, However Levofloxacin, Ceftriaxone and Norfloxacin revealed promising MIC activity.E.coli shows high resistance as compared to Salmonella and Shigella species.
Diarrhea, Ampicillin, Ceftriaxone, Norfloxacin, Nalidixic acid, Minimum Inhibitory Concentration (MIC)
© The Author(s) 2012. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.