ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Poonam Mishra Chatterjee1, Deepika Pandey Tiwari1, Ritu Raval1 and Ashok Kumar Dubey2*
1Department of Biotechnology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
2Department of Food Science and Technology, Tata Chemicals Ltd-Innovation centre, Survey Number 315, Hissa Number 1-4, Ambedveth, Paud Road, Mulshi, Pune – 412 111, Maharashtra, India.
J Pure Appl Microbiol, 2019, 13 (2): 741-756 | Article Number: 5575
Received: 13/03/2019 | Accepted: 05/05/2019 | Published: 28/06/2019

Popularity of Polyglutamate (PGA) in industrial applications has motivated an extensive research in the area of bioprocess engineering for its production, strain improvement, advancements in analytical methods and applications. Some facets of PGA still remain a challenge and offer the researchers with time consuming methods to seek deeper insights into the behaviour of molecules. A few simple analytical approaches have been explained which can be used to address those challenges. This review focuses on understanding each step involved in manufacturing, analysis and applications of PGA. An attempt is made towards understanding the chemistry of PGA and its interaction with various other compounds. Occurrence of PGA in various conformational states under the influence of different environmental conditions is discussed. The properties of the biopolymer largely depend on its chain length which in turn arises due to diverse conditions in which it is biosynthesized by the microorganisms. Applications of PGA in various fields of food, agriculture, medical, cosmetics etc. are also dependent on the molecular weight and conformations of PGA under the given set of conditions. A few major applications of PGA which make this biopolymer an industrially influential molecule have been described.


Polyglutamic acid, properties, conformations, applications.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.