ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access

Jimmy Narayan1, Ayaskanta Singh1 , Bimala Mishra2, Niranjan Rout3, Rabi Narayan Mallick2, A.K. Mohanty2 and Shivaram Prasad Singh4

1Department of Gastroenterology, IMS and SUM Hospital, Siksha O Anusandhan, Deemed to be University, Bhubaneswar, Odisha, India.
2Department of Pathology, S.C.B. Medical College, Cuttack, Odisha, India.
3Department of Onco-Pathology, Acharya Harihar Regional Cancer Center, Cuttack, Odisha, India.
4Department of Gastroenterology, S.C.B. Medical College, Cuttack, Odisha, India.
J. Pure Appl. Microbiol., 2019, 13 (4): 2021-2025 | Article Number: 5688
https://doi.org/10.22207/JPAM.13.4.13 | © The Author(s). 2019
Received: 02/07/2019 | Accepted: 18/10/2019 | Published: 04/12/2019
Abstract

Gastric cancer (GC) is one of the most common malignancies. Although Helicobacter pylori (H. pylori) is being recognized as a Type I carcinogen for GC and primary gastric lymphoma (PGL), yet many studies especially from the Indian subcontinent do not show any such association. The aim of the study was to evaluate the clinicopathological characteristics of gastric adenocarcinoma and to determine the association of H. pylori infection. This prospective study included 50 cases of histologically proven gastric adenocarcinoma. A detailed clinical history, physical examination and upper gastrointestinal endoscopy were done in all the cases and mucosal biopsies were taken from the growth and the surrounding mucosa. Rapid urease test (RUT) was done to diagnose H. pylori infection. 50 patients of functional dyspepsia were taken as controls. GC was more common in males (70%). The maximum cases were recorded in elderly persons, mostly from 5th to 6th decades. Anorexia (60%), dyspepsia (54%) and weight loss (24%) were the commonest clinical presentation. Most of the patients presented within 3-12 month of onset of symptom. In majority of cases, the lesion was confined to the antrum (62%) and body (26%) of the stomach. H. pylori infection was more commonly isolated from the antrum. H. pylori infection was not significantly associated with GC as compared to patients with functional dyspepsia. No association was found between H. pylori infection and gastric carcinoma. Probably gastric cancer is multifactorial disease where dietary, genetic and environmental factors play contributing roles.

Keywords

Gastric Neoplasm, India, Helicobacter pylori.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.