ISSN: 0973-7510

E-ISSN: 2581-690X

Hamed A. El-Serehy1,2 , Khaled A. Al-Rasheid1, Fahad Al-Misned1 and Golam Mortuza1
1Zoology Department, College of Science, King Saud University, Riyadh 1145, Saudi Arabia.
2Port Said University, Faculty of Science, Marine Science Department, Port Said, Egypt.
J Pure Appl Microbiol. 2014;8(5):3807-3812
© The Author(s). 2014
Received: 01/08/2014 | Accepted: 06/09/2014 | Published: 31/10/2014

Herpes simplex virus (HSV) primarily causes infections of the oral–facial, ocular or genital mucosa with high worldwide prevalence. The aim of this study is to evaluate antiviral properties of Citrus sinensis peel aqueous extract against herpes simplex virus type 1 (HSV-1) in vitro. HSV-infected Vero cells and cell-free virus suspensions were treated with orange peel extracts, and virus yield and infectivity were quantified by direct plaque assay. The results of the present study showed that C. sinensis peel aqueous extract, at 150 µg/ml provided 71.3% inhibition of plaque of HSV-1. The aquous extract showed 100% inhibition against HSV-1 at 200, 250 and 300 µg/ml. These properties suggest that this C. sinensis peel could provide advantage as a topical prophylactic/therapeutic agent for herpes infections.


Orange peel, Herpes simplex virus, Antiviral

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© The Author(s) 2014. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.