The era of vaccination dates back to over 200 years when Edward Jenner established human vaccination against smallpox. With the final declaration of eradication of smallpox by World Health Organization (WHO) in 1980, started a new generation of recombinant DNA technology. The advent of this technology facilitated researchers to develop vectored vaccines expressing heterologous antigens from different pathogens. Among them, poxvirus based vectors are most widely used vaccine vectors due to unique properties of this ds DNA virus, in terms of large genome size and insertion and deletion of comparatively wider stretch of specific genes, without compromising the ability of vectored virus to replicate in vitro/in vivo. This led to the generation of broad spectrum vectored vaccine backbone capable of inserting multiple epitopes of variety of pathogens, thus producing immunity against multiple diseases with a single injection. These recombinant vectored vaccines have an obvious potential in prophylaxis against devastating diseases in developing countries where cost, labor, lack of awareness about vaccination are main hindrances in successful control/eradication of diseases. In this review we have focused on various capripoxvirus based vectored vaccines with special reference to animal diseases, their future potential in developing countries like India, to be capable of protecting from multiple diseases.
Vaccination, in vitro, Vaccine Vector.
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