To understand the status of cadmium (Cd) accumulation and analyze the affecting factors in greenhouse soil under the intensive usage, 37 soil samples from greenhouse fields and 6 soil samples from local open fields were collected in eastern Shandong province. The range and average of Cd concentration in topsoil (0-20 cm) were 0.20-1.67 and 0.52 mg/kg, and 0.21-1.44, 0.47 mg/kg in subsoil (20-40 cm), respectively. 78.4 percent of the samples topsoil and 70.3 percent of subsoil exceeded soil environmental quality standard of China. It showed that Cd contamination of greenhouse soils in eastern Shandong is quite serious. Cd content in topsoil was extremely significant positive correlated with soil organic matter and total N. Due to the universal high input of organic/chemical fertilizers in the study area, Cd content in soil increased significantly with the increase of cultivating years. The present study indicates that long-term and excessive usage of nitrogen and organic fertilizer are an important cause leading to Cd accumulation in greenhouse field soils in eastern Shandong province. Most importantly, the widespread secondary salinization and acidification in greenhouse soil may further increase of Cd bioavailability in soil and accordingly enhance the health risk of people via eating vegetables.