ISSN: 0973-7510

E-ISSN: 2581-690X

R.H. Patil , S.V. Patil1, J.A. Rajput1, Javed Bhat1, R.G. Chaudhary1, U.K. Patil and S.B. Chincholkar5
*Department of Microbiology, R.C.Patel Arts, Commerce and Science College, Shirpur, India.
1Department of Microbiology, School of Life sciences, North Maharashatra University, Jalgaon – 425 001, India.
J Pure Appl Microbiol. 2008;2(1):211-214
© The Author(s). 2008
Received: 08/02/2008 | Accepted: 20/03/2008 | Published: 30/04/2008

Studies on Biotransformation of rifamycin B to rifamycin S revealed that immobilized mycelia of Curvularia lunata are more efficient than free cells of organism with respect to time, cultural conditions and cost. Effect of various polymers revealed that carboxymethylcellulose has stimulatory effect on biotransformation whereas other polymers do not show significant effect on biotransformation. TLC analysis of transformed product shows two bands, one matching with standard rifamycin B while another with standard rifamycin S indicates significant transformation. Optimum transformation takes place at 400c and pH7 respectively. UV-Visible spectrophotometric studies indicated that rifamycin B and rifamycin S has absorption maxima 425 and 525 respectively.


Biotransformation, rifamycin B, rifamycin S, TLC, Curvularia lunata

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