ISSN: 0973-7510

E-ISSN: 2581-690X

M.E. Shelke
Department of Chemistry, H.V.P.M. College of Engineering and Technology HVPM Campus, Amravati – 444 606. India.
J Pure Appl Microbiol. 2007;1(1):133-135
© The Author(s). 2007
Received: 12/02/2007 | Accepted: 17/03/2007 | Published: 30/04/2007

Novel series 2-(1-substitutedguanidino-3-yl)-4-(3-phenylthiocarbamido-1-yl)-6- substituted imino-1,3,5-thiadiazine [3a(i) to 3f(ii)] have been obtained by basification of their hydrochlorides [2a(i) to 2f(ii)] in presence of ammonium hydroxide solution, which are synthesized by the interaction of 1-Formamidino- (n- substitutedthioamido)-5-phenyl-2-thio-4-iminobiuret (1a-f) and N-aryl/alkylisocyanodichlorides. The latter were prepared initially by the condensation of substitutedisothiocyanate with N-phenylformamidi-noformamidinothiocarbamide. The structure of all these compounds were established on the basis of elemental analysis, IR and PMR spectral data. All the synthesized compounds have been assayed for their antimicrobial activity against both gram-positive and gram-negative human pathogens and found that they possess insecticidal, and bacteriocidal.  Some 1,3,5-thiadiazine compounds show remarkable biological activity.


N-phenylformamidinoformamidinothiocarbamide, 1,3,5-thiadiazines, antimicrobial activity

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