ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access

Rusul Malik Al-Dedah1 , Wafaa S. Al-wazni1, Mohammed Talat abbas2, Hussein H. Al-Ghanimi3 and Fatema Abduallah4

1Department of Biology, College of Science, University of Kerbala, Kerbala, Iraq.
2Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Kerbala, Iraq.
3Department of Pathological Analysis Techniques, IbnHayyan University College, Kerbala, Iraq. 4Immunology Laboratory, Hussein Teaching Hospital, Kerbala, Iraq.
J Pure Appl Microbiol. 2018;12(4):1965-1973 | Article Number: 5261
Received: 18/08/2018 | Accepted: 23/09/2018 | Published: 30/12/2018
Abstract

Thalassemia is a genetic disorder occurs as a result of the imbalance in the construction of haemoglobin chains cause haemolytic anaemia. This study was aimed to evaluate the serum level of immunological parameters (Transforming growth factor beta1, Interleukin-23) and hematological parameters in patients with alpha and beta thalassemia at Kerbala province. And was conducted at Kerbala Children’s Hospital / Thalassemia Department / Kerbala Governorate during the period from November 2017 to May 2018. Seventy patients involved 48 beta thalassemia patients and 22 alpha thalassemia patients with age ranged 10-20 years old and ten matched healthy controls were enrolled in the study. Result exposed non-significant increase (p>0.05) in IL-23 and TGF-b in thalassemia patients compared with control group. In b-thalassemia patients the results of the current study indicated that non-significant positive correlation between IL-23 with WBC, there was non-significant positive correlation between TGF-β1 with WBC and PLT. As for β-thalassemia patients the present study showed non-significant positive correlation between IL-23 with Hb and WBC, and there was non-significant positive correlation between TGF-β1 with WBC. The study showed changes in the immunological parameters in patients with thalassemia of both types, as the serum level of both IL-23 and TGF-b1 were raised in addition to changes in hematological and Biochemical parameters.

Keywords

a-thalassemia, β-thalassemia, TGF-β1, IL-23, hematological parameters, liver function, kidney function

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