ISSN: 0973-7510
E-ISSN: 2581-690X
Diabetic Nephropathy is a microvascular complication of diabetes, representing the leading cause of end stage renal disease in the world, and a major cause of morbidity and mortality in type 2 diabetic subjects. The aim of the study was to evaluate the effect of antioxidant enzymes on Diabetic Nephropathy patients. Superoxide dismutase (SOD), Catalase, Malondialdehyde (MDA), fasting blood sugar, serum urea, serum creatinine and serum uric acid were assayed in 160 subjects In which 71 Diabetic Nephropathy patients, 36 Nephropathy patients without diabetes and 53 healthy control. In our study, we found statistical significantly decrease SOD, Catalase level and increase production of MDA in DM-CKD and also found deranged renal function. Reduced activity of serum antioxidant enzymes and increased level of MDA were observed in Diabetic Nephropathy patients compare to healthy control.
Diabetes mellitus (DM), Chronic kidney disease (CKD), Oxidative stress, Urea, Creatinine, Uric acid
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