ISSN: 0973-7510

E-ISSN: 2581-690X

Meena Varma, Jaidev Singh and Sangeeta Paneri
Deparment of Biochemistry M.G.M. Medical College, Indore, India.
J Pure Appl Microbiol. 2011;5(1):481-484
© The Author(s). 2011
Received: 27/08/2010 | Accepted: 07/10/2010 | Published: 30/04/2011

Beta thalassemia is a single gene disorder requiring regular multi-blood transfusions which causes serious side effects, as an overload of iron in the form of ferritin. We determined whether thalassemia could account for abnormal cation transport system. Traditionally serum iron, ferritin, TIBC and the % saturation, an indirect measurement of transferrin, have been used to determine iron status.The present study included 100 multitransfused thalassemic children and 35 control, in the age group of 3-10 years. Serum ferritin was evaluated by ELISA method, urea by Berthelot method, creatinine by Jaffes reaction & TIBC by Ramsay Dipyridyl method. It has been found that the serum ferritin level was significantly  increased in thalassemic children as compared to control  due to the regular blood transfusions.Serum kidney enzymes were also deranged. Serum ferritin, urea & creatinine levels increased and TIBC decreased. As the number of blood transfusion increases, the serum ferritin,urea & creatinine  also significantly increases while ,TIBC decreases. Hence, it can be concluded from the present study that increased serum ferritin, urea, creatinine and decreased TIBC levels are associated with multi-transfused children.


Beta thalassemia, Kidney function test, Multi-blood transfusions

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© The Author(s) 2011. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.