Beta thalassemia is a single gene disorder requiring regular multi-blood transfusions which causes serious side effects, as an overload of iron in the form of ferritin. We determined whether thalassemia could account for abnormal cation transport system. Traditionally serum iron, ferritin, TIBC and the % saturation, an indirect measurement of transferrin, have been used to determine iron status.The present study included 100 multitransfused thalassemic children and 35 control, in the age group of 3-10 years. Serum ferritin was evaluated by ELISA method, urea by Berthelot method, creatinine by Jaffes reaction & TIBC by Ramsay Dipyridyl method. It has been found that the serum ferritin level was significantly increased in thalassemic children as compared to control due to the regular blood transfusions.Serum kidney enzymes were also deranged. Serum ferritin, urea & creatinine levels increased and TIBC decreased. As the number of blood transfusion increases, the serum ferritin,urea & creatinine also significantly increases while ,TIBC decreases. Hence, it can be concluded from the present study that increased serum ferritin, urea, creatinine and decreased TIBC levels are associated with multi-transfused children.
Beta thalassemia, Kidney function test, Multi-blood transfusions
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