Attempts were made to study the antioxidant and cytotoxic activities of compounds produced by Streptomyces albidoflavus. Bioactive metabolites were obtained from the crude solvent extract of culture broth collected after five days incubation of the strain. Two bioactive compounds were purified and characterized as anthracene-9,10-quinone and 8-hydroxyquinoline. Antioxidant activity of these compounds was studied by superoxide free radical scavenging activity. The compound 8-hydroxyquinoline exhibited good antioxidant properties over BHA but less activity than vitamin C. Cytotoxicity of the compounds was tested on U-937, HeLa and THP-1 cell lines. Of the two bioactive compounds isolated from strain, 8-hydroxyquinoline was found to possess significant cytotoxicity on tested cell lines.
Streptomyces albidoflavus Antioxidant activity, Cytotoxicity
Share This Article
© The Author(s) 2008. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.