Antimicrobial Evaluation of Some Pyridone and Hydantoin N-glycosides Carrying Pyrene Moiety

ISSN: 0973-7510

E-ISSN: 2581-690X

Nagy M. Khalifa^1,2 , Mohamed A. Al-Omar¹, Abd El-Galil E. Amr^1,3 and Sherein I. Abd-Elmoez⁴

¹Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC),
College of Pharmacy, King Saud University, Riyadh, 11451 Saudi Arabia.

²Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division,
National Research Centre, 12622-Dokki, Cairo, Egypt.

³Applied Organic Chemistry Department, National Research Centre, 12622-Dokki Cairo, Egypt.

⁴Microbiology and Immunology Department, National Research Centre, El-Behoos Street, Dokki,Cairo 12622, Egypt.

J Pure Appl Microbiol. 2014;8(Spl. Edn. 2):505-510

Received: 30/08/2014 | Accepted: 21/10/2014 | Published: 30/11/2014

Abstract

In our previous work, some of imidazole and pyridone carrying pyrene derivatives were synthesized before. The potential antimicrobial effects of the synthesized compounds were screened for qualitative (zone of inhibition) and quantitative antibacterial activity (MIC) by agar diffusion test and microtitration methods, respectively, using a variety of microorganisms (S. Typhimurium and P. aeruginosa ) as Gram –ve bacteria, (S. aureus) as Gram +ve bacteria and (C. albicans and A. flavus) as yeast. Some of them exhibited promising activities and the other compounds exhibited moderate activity when compared to standard reference drug.

Keywords

Imidazole derivatives, Pyridones, glycosides, Antimicrobial activities

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