Novel series of ring junction N-substituted pyrimidine derivatives viz. 7-(Sub-phenyl)-6-(sub-benzoyl)-5-methyl-2,4,7-tetrahydro-3,4,8-triazainden-1-ones III(1-16)have been synthesized by Cyclocondensation of 6-Methyl-5-(sub-benzoyl)-4-(sub-phenyl)-3,4-dihydro-1-H-pyrimid-2-one/thiones with amino acid such as glycine by using microwave assisted method in presence of POCl3 + PPA mixture acts both as a catalyst and as a solvent which makes the process eco-friendly, economic and easy. The structures of the synthesized compounds have been conformed on the basis of IR,H1-NMR,UV and Elemental analysis. Some of them have been screened for their antimicrobial activitity against fungal pathogens like Aspergillus oryzae and Fusarium oxysporum and bacterial pathogens like E-coli (Gram –ve) and Staphylococci (Gram +ve) . Also cytotoxicity and phytotic(antifungal) effects of some newly synthesized compounds on crop plants Vigna radiata (Green gram) and Gossypium herbaceum L. (Cotton) have been checked.
Pyrimidines, Cyclocondensation, Microwaves, Cytotoxicity, Antimicrobial activity
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