Antimicrobial Activity of Ethanolic leaf extract of Intigofera aspalathoides and Plectranthus caninus against some human pathogenic bacteria and fungi were evaluated. The extracts of these plants were evaluated for antimicrobial activity against human pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Salmonella typhii and pathogenic fungi such as Aspergillus flavus and Aspergillus ochraceous. Ethanolic leaf extracts were prepared and based on the susceptibility of the test organisms were determined. It was found that ethanolic extracts showed high inhibition zone than control experiments.