ISSN: 0973-7510

E-ISSN: 2581-690X

M.E. Shelke
Department of Chemistry, H.V.P.M. College of Engineering and Technology, HVPM Campus, Amravati, India.
J Pure Appl Microbiol. 2007;1(2):351-353
© The Author(s). 2007
Received: 22/05/2007 | Accepted: 02/07/2007 | Published: 30/10/2007

Novel series of 1-substituted-2-thio-(1H)-4-(1-substitutedthiocarbamido-3-yl)-6-substitutedamino 1,2-dihydro-s-triazines[3a(I) to 3f(III)]  have been obtained by the isomerisation of 2-substitutedamino-4-(1-substitutedthiocarbamido-3-yl)- 6-substitutedimino-1,3,5-thiadiazines[2a(I) to 2f(III)] in presence of ethanolic sodium bicarbonate solution, which have been obtained by basification of their hydrochlorides [1a(I) to 1f(III)] which are synthesized by the interaction of 1,3-Bis-(n- substitutedthioamido) guanidine and N-aryl/alkylisocyanodichlorides. The latter were prepared initially by the condensation of guanidine carbonate and N-substitutedisothiocyanate. The structure of all these compounds was established on the basis of elemental analysis, IR and PMR spectral data. All the synthesized compounds have been screened for their antimicrobial activity against both gram-positive and gram-negative human pathogens.


1,3-Bis-(n- substitutedthioamido) guanidine, 1,3,5-thiadiazines, S-triazines, antimicrobial activity

Article Metrics

Article View: 597

Share This Article

© The Author(s) 2007. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.