Antifungal vs. Antibacterial Activity of α,β-unsaturated Carbonyl Compound

ISSN: 0973-7510

E-ISSN: 2581-690X

R.C. Jagessar¹ and S. Gomathinayagam²

¹Department of Chemistry, University of Guyana, Faculty of Natural Sciences, Turkeyen Campus, South America.

²Department of Microbiology, Berbice Campus, John’s, University of Guyana, Berbice, South America.

J Pure Appl Microbiol. 2010;4(1):63-68

Received: 07/08/2009 | Accepted: 26/09/2009 | Published: 30/04/2010

Abstract

Antimicrobial activity of two a,b-unsaturated carbonyl compounds, 9-(propan-3-ene-1-methyl-2-one) anthracene (5) and trans, trans –dibenzylidene acetone (7) were investigated using the Agar diffusion and Poison plate methods. Compounds were synthesized via the aldol route in very good yields and were characterized via ¹H NMR, ¹³C NMR, DEPT-135 and IR spectroscopy. Both compounds were found to be antimicrobial. However, their mode of action was more antibacterial than antifungal.

Keywords

Antimicrobial activity, α,β-unsaturated carbonyl compounds, Agar well diffusion, poison plate methods and spectroscopy

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