Staphylococcus aureus causes infection ranging from mild skin infection to fatal life threatening infections. Nowadays, Methicillin resistant Staphylococcus aureus (MRSA) which do not respond to commonly used antibiotics has emerged posing serious threat in health care settings which aimed to study the susceptibility pattern of MSSA and MRSA among inpatients and outpatients in our hospital. This study included 159 strains of S. aureus isolated from various clinical specimens collected from April 2018 – March 2019. Standard isolation techniques and identification protocols were followed. Among the total 159 Staphylococcal isolates, 134 isolates and 25 isolates were isolated from inpatients and outpatients respectively. Methicillin resistance was seen in 67.3% (107/159) of the total isolates, among which 69.4% (93/134) were from inpatients and 56% (14/25) were from outpatients. Among these total MRSA, 38% were reported from urine followed by pus and blood samples. Antibiotic susceptibility pattern revealed that 75% of MSSA strains were sensitive to doxycycline and Clindamycin. Among the MRSA isolates 95.3% were resistant to Ampicillin and 86.9%, 73.8%, 60.7%, 52.3% and 50.4% isolates were resistant to erythromycin, Co-trimoxazole, Ciprofloxacin, Moxifloxacin and Clindamycin respectively. All MRSA isolates were sensitive to vancomycin while 97.2% were sensitive to Linzolide. S. aureus isolated from urine showed high resistance of 89% and sensitivity of 92.7% to norfloxacin and nitrofurantoin respectively. This study reports high prevalence of MRSA. This study helps to select the appropriate antibiotic for proper patient care in this area and insist upon to follow strict hospital Infection control practices in this hospital.