ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Nur Arifah Ismail, Khairul Anuar Mat Amin and Mohd. Hasmizam Razali
School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu Darul Iman, Malaysia.
J Pure Appl Microbiol, 2019, 13 (2): 1095-1102 | Article Number: 5504
Received: 30/01/2019 | Accepted: 07/03/2019 | Published: 21/06/2019
Abstract

A series of norfloxacin-loaded films were fabricated by combining with gellan gum (GG) using evaporative casting technique. The films were evaluated in terms of morphological, water vapour transmission rates (WVTR), water uptake, release study and antibacterial study. The prepared films contained smooth appearance of cross-section distributed by good film of materials. The results indicated that the film swelling were increased at higher concentration of norfloxacin loaded, however decreased the WVTR properties. All films showed almost 100 % of drug release within 5 – 20 minutes. It was found that, the antibacterial activity was directly proportional to the release rate which is at higher concentration of norfloxacin resulted in stronger antibacterial properties.

Keywords

Gellan gum; Film; Antibacterial.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.