Antagonistic Activity of Nocardia brasiliensis PTCC 1422 Against Isolated Gram-negative Bacteria from Urinary Tract Infections

ISSN: 0973-7510

E-ISSN: 2581-690X

Antagonistic Activity of Nocardia brasiliensis PTCC 1422 Against Isolated Gram-negative Bacteria from Urinary Tract Infections

Hossnieh Kafshdar Jalali¹, Khosro Issazadeh¹ , Mohammad Reza Majid Khoshkholgh Pahlaviani², Naeem Momeni¹ and Alireza Massiha²

¹Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University,
Lahijan Branch, Lahijan, P.O. Box 1616, Iran.

²Department of Biotechnology, Faculty of Basic Sciences, Islamic Azad University, Lahijan Branch, Lahijan, P.O. Box 1616, Iran.

J Pure Appl Microbiol. 2014;8(4):3075-3078

Received: 08/03/2014 | Accepted: 15/04/2014 | Published: 31/08/2014

Abstract

The nocardiae are bacteria belonging to the aerobic actinomycetes. They are partially acid fast, Gram-positive, branching filamentous bacteria that are found ubiquitously in soil, fresh water and marine water. Bacterial urinary tract infections are frequent in the outpatient as well as in the nosocomial setting. The common bacteria from UTIs were isolated from hospital and laboratory samples. The present study was designed to isolate Gram- negative bacteria from urinary tract infections and evaluate Nocardia brasiliensis PTCC 1422 antimicrobial activity against pathogenic bacteria. Bacterial isolates were identified as Acinetobater spp. and Pseudomonas aeruginosa. The cell free supernatants of the N. brasiliensis were able to inhibit the growth of all human pathogens (Acinetobater spp. and Pseudomonas aeruginosa) isolated in this study in Well diffusion method. The isolates also showed very promising activities against multi drug resistant human pathogens.

Keywords

N. brasiliensis, Urinary Tract Infections, Antagonistic activity

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