Candida krusei is a non-albicans Candida species that has been reported to exhibit intrinsic resistance to several antifungal agents, making infections caused by this organism challenging to control and highlighting the need for effective antiseptic alternatives. The exploration of plants with antifungal activity became an important area of research because of the increasing demand for effective and safe natural antiseptic alternatives. In this study, we evaluated the potential of extracts of Moringa oleifera and Centella asiatica extracts as antiseptic agents, either individually or in combination, against C. krusei. The antifungal activity of the extracts was evaluated using a time-kill assay at different concentrations. Fungal viability was assessed at 1, 2, and 5 minutes after exposure and expressed as the percentage of fungal killing. The antifungal activities of the individual and combined extracts were compared at each contact time. Both M. oleifera and C. asiatica extracts exhibited concentration- and time-dependent fungicidal activity against C. krusei. The C. asiatica extract showed greater antifungal activity than the M. oleifera extract at the tested concentrations. The combination of M. oleifera (300 mg/mL) and C. asiatica (250 mg/mL) extracts showed rapid fungicidal activity against C. krusei, with killing rates of 80.0% at 1 minute, 90.0% at 2 minutes, and 97.0% at 5 minutes. Phytochemical analysis showed that C. asiatica had higher total phenolic and flavonoid contents than M. oleifera. The total phenolic content was approximately 16.6 mg GAE/g for M. oleifera and 22.1 mg GAE/g for C. asiatica, while the total flavonoid content was approximately 1.6 mg QE/g and 6.6 mg QE/g, respectively. The individual and combined extracts demonstrated rapid fungicidal activity against C. krusei in vitro, with the combined extracts showing greater killing activity than the individual extracts at the tested concentrations. Further studies are needed to elucidate the mechanisms of action, determine the optimal formulation, and evaluate the safety and efficacy of these extracts for antiseptic applications.