ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Abhipsa Samal1, Bhabani S.T.P. Singh2 , Bikash Ranjan Kar2 and Liza Mohapatra2
1Department of Dermatology, SCB Medical College and Hospital, Cuttack, Odisha, India.
2Department of Dermatology, IMS and SUM Hospital, K8 Kalinga Nagar, Bhubaneswar, Odisha, India.
Article Number: 9213 | © The Author(s). 2024
J Pure Appl Microbiol. 2024;18(4):2885-2894. https://doi.org/10.22207/JPAM.18.4.59
Received: 17 December 2023 | Accepted: 13 November 2024 | Published online: 27 November 2024
Issue online: December 2024
Abstract

Dermatophytosis is a superficial fungal infection involving the keratinized tissues. Limited dermatophytosis is usually treated with topical antifungals. Amorolfine and luliconazole are relatively newer and superior topical antifungals much in use in recent times.  To study the therapeutic efficacy and safety of luliconazole 1% and amorolfine 0.25% cream in patients with tinea cruris.  A single-center, randomized, double-blind, non-inferiority study comparing luliconazole and amorolfine was conducted on patients with localized tinea cruris. 81 patients completed the study, with 40 patients treated with luliconazole and 41 patients treated with amorolfine. Both groups of patients were followed up at the end of 2 weeks. No statistically significant difference was found between luliconazole and amorolfine regarding improvement in erythema, scaling, pruritus, and mycological cure. Both the medications were safe and well tolerated by the patients. The duration of the study was short, and there was no long-term follow-up. Amorolfine is not inferior to luliconazole in treating limited tinea cruris.

Keywords

Tinea cruris, Topical Antifungal, Luliconazole, Amorolfine

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