ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Taru Saklani1, Naveen Chandra Joshi2 and Vikash Jakhmola1
1Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand – 248007, India.
2Division of Research & Innovation, Uttaranchal University, Dehradun, Uttarakhand – 248007, India.
Article Number: 9225 | © The Author(s). 2024
J Pure Appl Microbiol. 2024;18(2):1013-1024. https://doi.org/10.22207/JPAM.18.2.16
Received: 04 January 2024 | Accepted: 01 April 2024 | Published online: 02 May 2024
Issue online: June 2024
Abstract

In this work, Azadirachta indica leaf extract and the ultrasonic method were applied for the fabrication of a CuO/Ag-based nanocomposite. The CuO/Ag was characterised using different analytical methods such as FTIR, SEM, EDX, and XRD. The well diffusion method was used to evaluate the antibacterial activity of non-calcined and calcined CuO/Ag against some hazardous bacterial strains. After the incubation period, remarkable zones of inhibition were observed around the loaded CuO/Ag. The maximum zones of inhibition were found to be 17.9 (± 0.39), 20 (± 0.17), and 14.3 (± 0.31) mm for E. coli, S. aureus, and S. enterica, respectively. Experimental findings indicated that non-calcined CuO/Ag was a more effective antibacterial agent as compared to calcined CuO/Ag.

Keywords

Azadirachta indica, Leaf Extract, CuO/Ag, Antibacterial Activity

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