ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Debolina Chatterjee and Karthikeyan Sivashanmugam
School of Biosciences and Technology, Vellore Institute of Technology SBST, Vellore, Tamilnadu, India.
Article Number: 9123 | © The Author(s). 2024
J Pure Appl Microbiol. 2024;18(2):837-852. https://doi.org/10.22207/JPAM.18.2.08
Received: 10 November 2023 | Accepted: 20 March 2024 | Published online: 25 April 2024
Issue online: June 2024
Abstract

Diabetic foot ulcers (DFU) in patients with uncontrolled diabetes mellitus are considered a global public health menace that is highly associated with morbidity and mortality. Pathogenic microorganisms entrenched deep into diabetic foot wounds are the causative agents for delayed healing and escalation of diabetic foot wound severity. Pseudomonas aeruginosa is a common opportunistic pathogen associated with several nosocomial infections, cystic fibrosis, and one of the most critical pathogens often isolated from acute and chronic diabetic foot ulcers. The organism can exhibit resistance to a wide range of antibiotics like ciprofloxacin, cefotaxime, and meropenem, thereby causing severe damage to the host tissues, followed by amputation of the affected foot region. Due to their ability to synthesize biofilms, the wound becomes more chronic and incurable, posing a serious threat to immunocompromised diabetic patients. This review highlights on the insights of pathophysiology and microbiological profile of Diabetic foot ulcers, the resistance mechanisms, and the therapeutics available for dealing with drug-resistant Pseudomonas, which could help clinicians in treating DFUs.

Keywords

Pseudomonas aeruginosa, Diabetic Foot Ulcers, Biofilm, Antibiotic Resistance, Quorum Sensing

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© The Author(s) 2024. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.