Antibiotics are an essential part of modern healthcare, revolutionizing medicine and saving countless lives worldwide. However, the emergence of antimicrobial resistance (AMR) is a growing concern, with the potential to cause a public health crisis in the future. The aim of this review article is to provide an overview of the microbial and anthropogenic factors contributing to AMR, as well as the consequences of inaction to address the AMR crisis. We searched various international databases such as PubMed, Scopus, ScienceDirect and Google Scholar using “Antimicrobial Resistance”,” Superbug”, “Antibiotic Stewardship”, “One Health’ and “Surveillance” as search keywords in different combinations. We have thoroughly discussed the causes of AMR, such as the overuse and misuse of antibiotics, and the development of resistant strains of bacteria. We have also suggested possible interventions to combat AMR, such as the one health approach, antibiotic stewardship protocols, and the application of artificial intelligence in drug design. Additionally, we have explored the benefits of traditional ethnic medicinal practices in therapy. In conclusion, this review article emphasized the urgent need for a comprehensive and strategic plan to address the issue of AMR. Further in-depth research and novel approaches can mitigate the growing menace of AMR and safeguard both human and animal populations.