ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Umamakeshwari Dhanalakshmi Jeyaraman, Padmakumari Jagadeesan , Vinotha Sundaram and Vanaja Rebba
Institute of Microbiology, Madras Medical College, Chennai, Tamil Nadu, India.
Article Number: 8818 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(4):2179-2187. https://doi.org/10.22207/JPAM.17.4.14
Received: 03 July 2023 | Accepted: 22 September 2023 | Published online: 23 October 2023
Issue online: December 2023
Abstract

Among patients admitted to the intensive care unit (ICU) the most common cause of infection is lower respiratory tract infections, which account for 4.4% of hospital admissions. Among the non-fermenters, Pseudomonas aeruginosa and Acinetobacter calcoaceticus-baumannii complex, cause many types of nosocomial infections. Ventilator-associated pneumonia is the most common emerging infection among them. The goal of this study was to isolate and speciate non-fermenting Gram-negative organisms from respiratory samples of ICU patients and to detect antimicrobial susceptibility patterns of the isolated non-fermenters. This cross-sectional study was conducted at the Institute of Microbiology in collaboration with Medical Intensive Care units in Rajiv Gandhi Government General Hospital. A total of 200 patients who satisfied the inclusion criteria were included in the study conducted between March 2019 and March 2020. Culture, sensitivity, and anti-microbial susceptibility tests were performed for the respiratory samples collected as per standard protocols. Pseudomonas aeruginosa (49%) was the most commonly isolated non-fermenter followed by Acinetobacter baumannii (24.3%). Among Pseudomonas aeruginosa isolates, the highest percentage were ESBL producers (44.4%). Carbapenem resistance among Pseudomonas isolates was 33%. The study showed increased isolation of MDR non-fermenters from the ICU causing Ventilator-associated pneumonia (VAP). To prevent VAP caused by these MDR pathogens, clinicians should follow strict infection control practices, use invasive devices on a short-term basis, and use antibiotics judiciously.

Keywords

Non-fermenters, Ventilator Associated Pneumonia(VAP), Pseudomonas aeruginosa, Acinetobacter baumannii

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.