ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Abishkauf Jenish Beautlin1 , Ashok Govindaraj1, Durga Devi1, Gurubharath Ilangovan2 and Divya Lakshmi1
1Department of Cardiology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
2Department of Radiology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Article Number: 8752 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(4):2157-2164. https://doi.org/10.22207/JPAM.17.4.12
Received: 05 June 2023 | Accepted: 04 September 2023 | Published online: 23 October 2023
Issue online: December 2023
Abstract

Cardiovascular disorders have been linked to myeloperoxidase, an enzyme generated from leukocytes. MPO creates an antibacterial system and has been many correlations between MPO, hs-CRP and cardiovascular disease. The present study has aimed to assess MPO, hs-CRP and subclinical atherosclerosis in metabolic syndrome patients by using FMD and CIMT parameters. 75 metabolic syndrome affected patients had defined as per the criteria of IDF (International Diabetes Federation) which had been in this study. In addition, ultrasound doppler had been employed for determining the carotid intima medial thickness for both right and left (left and right CIMT) and brachial artery FMD. By employing the Immunoassay MPO and hs-CRP ultrasensitive ELISA kit, the concentration of MPO and hs-CRP is measured. A positive link between MPO with CIMT right and left (r value of right CIMT=0.723, p <0.05 and left CIMT r=0.712, p<0.01), hs-CRP with CIMT right and left (r value of right CIMT=0.613, p<0.05and left CIMT r=0.64, p<0.01)and a significant inverse correlation between MPO with FMD (r= -0.319,p<0.05), hs-CRP with FMD (r= -0.304,p<0.01) in metabolic syndrome patients. Serum MPO and hs-CRP is positively linked with subclinical atherosclerosis in metabolic syndrome patients. According to this finding, understanding the mechanism behind the risk factors for cardiovascular disease can be aided by the development of new molecular markers for metabolic syndrome and subclinical atherosclerosis.

Keywords

Flow Mediated Vasodilatation, Carotid Intima Medial Thickness, Metabolic Syndrome, hs-CRP, Myeloperoxidase

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.