ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Niharika Pandey1, Firoz Ahmad1, Kratika Singh1, Pranshu Pandey2 and Rolee Sharma1,3
1Department of Biosciences, Integral University, Lucknow, Uttar Pradesh, India.
2Department of Microbiology, Maharshi Devraha Baba Autonomous State Medical College,
Deoria, Uttar Pradesh, India.
3Department of Life Sciences and Biotechnology, CSJM University, Kanpur, Uttar Pradesh, India.
Article Number: 8624 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(4):2010-2023. https://doi.org/10.22207/JPAM.17.4.04
Received: 14 April 2023 | Accepted: 07 September 2023 | Published online: 13 October 2023
Issue online: December 2023
Abstract

Tuberculosis (TB) is a contagious disease that is a significant cause of illness worldwide and has been declared one of the top ten causes of mortality across the world. It is well known that bacteria within biofilms exhibit much higher drug resistance than individual cells. Biofilms constitute a significant threat in the clinical environment by acting as reservoirs of multidrug-resistant bacteria. Thus, the formation of biofilms has been postulated to further aid in drug insensitivity and bacterial persistence within host tissues. The rapid increase in drug resistance in Mycobacteria poses a significant challenge to TB eradication and needs to be addressed soon. In this review, we have attempted to frame a general overview of mycobacterial pathogenesis, the role of biofilm formation in enhancing its shelf life, and some natural compounds and nanoparticles as emerging novel therapeutics reported to inhibit biofilm formation in mycobacteria. Therefore, we present some recent advances which might have potential applications in new treatment regimens for Tuberculosis.

Keywords

Biofilm, Mycobacteria, Therapeutics, Tuberculosis

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.