ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Hayat A. Al-Btoush
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak, 61710, Jordan.
Article Number: 8963 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(4):2024-2040. https://doi.org/10.22207/JPAM.17.4.03
Received: 30 August 2023 | Accepted: 25 September 2023 | Published online: 13 October 2023
Issue online: December 2023
Abstract

The use of metallic nanoparticles (NPs) in various industrial and biomedical fields is increasing exponentially. As a result, research examining the potentially toxic impact of these NPs on human health is also increasing. Cytochrome P450 (P450s) enzymes are important for the endogenous and exogenous molecules metabolism. Inhibition or induction of these enzymes affects xenobiotic detoxification and causes clinically significant drug toxicity or therapeutic failures. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are the most frequently used biomarker for liver injury and their induction is an important indicator of hepatotoxicity. This review aims to understand the existing literature relevant to the effect of metallic NPs on P450s, ALT and AST (aminotransferases) enzymes. It was found that the predominant effect of metallic NPs is the inhibition of the CYP 450 gene and protein expression and induction of aminotransferases, which highlights their potential interaction and induction of drug-associated toxicity as well as their hepatotoxicity. However, further studies are recommended to investigate the effect of NPs size, morphology, surface area, charge, and NPs coating on the expression of these enzymes.

Keywords

Cytochrome P450, Alanine Aminotransferases, Aspartate Aminotransferases, Metallic Nanoparticles, Induction, Inhibition

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.