ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Haris Variyathody1, Malarvizhi Arthanari1, Manohar Murugan2 and Gobianand Kuppannan1
1Department of Microbiology, Vivekanandha College of Arts and Sciences for Women (Autonomous), Elayampalayam, Tiruchengode, Namakkal (DT), Tamilnadu, India.
2Department of Microbiology, Sadakathullah Appa College, Rahmath Nagar, Tirunelveli, Tamil Nadu, India.
Article Number: 8634 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(4):2080-2097.
Received: 18 April 2023 | Accepted: 26 July 2023 | Published online: 02 October 2023
Issue online: December 2023

Millions of people die every year as a result of infections’ multidrug resistance (MDR) pathogens. Therefore, the creation of novel antibiotics is urgently required for the treatment of bacterial illnesses that are resistant to a variety of drugs. The current study concentrated on the development of copper oxide nanoparticles conjugated with Vitamin-E (CuO NPs-Vit E complex), which was evaluated using various approaches like FTIR (Fourier transform infrared spectroscopy), UV-Vis (ultraviolet-visible spectroscopy), SEM (scanning electron microscopy), XRD (X-ray diffraction). The antibacterial and anti-biofilm activity was investigated against MDR Escherichia coli and Staphylococcus aureus. The antioxidant properties of CuO NPs-Vit E complex were determined using DPPH and FRAP assay. The CuO NPs-Vit E complex showed excellent anti-bacterial, anti-biofilm, and antioxidant activities. Moreover, it was found to be biocompatible and non-toxic to normal cells. Therefore, the synthesized CuO NPs-Vit E complex can be used for the creation of new drugs for the treatment of multidrug-resistant bacterial infections.


Anti-bacterial, Anti-biofilm, Antioxidant, Copper Nanoparticles, Multidrug Resistance, Vitamin-E

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.