ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Jehad A. Aldali1 , Shar A. Alahmari2, Abeer O. AlMezyed3, Nawal S.D. Alshammari4 and Emadeldin M. Elsokkary5
1Department of Pathology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia.
2Department of Pathology, College of Medicine, King Saud University, Riyadh 145111, Saudi Arabia.
3Microbiology Department, King Fahad Medical City, Riyadh 11525, Saudi Arabia.
4Genomic Research Department, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh, Saudi Arabia.
5Department of Psychology, Imam Mohammad Ibn Saud Islamic University, Riyadh 13317, Saudi Arabia.
Article Number: 8853 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(3):1836-1845. https://doi.org/10.22207/JPAM.17.3.48
Received: 17 July 2023 | Accepted: 21 August 2023 | Published online: 03 September 2023
Issue online: September 2023
Abstract

The study reveals crucial information on S. capitis, a potentially dangerous bacterium that can cause sepsis in hospitalized adult patients, including its frequency and patterns of drug resistance which could significantly contribute to the existing body of knowledge in this field. This retrospective study was conducted in the King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, from June 2019 to November 2022. The comprehensive data collection and analysis provide valuable information on the prevalence of S. capitis in different infection sites, antibiotic sensitivity profiles, and the association with patient demographics. A total of 219 S. capitis isolates from hospitalized patients with sepsis tested positive. Infection was most common in venous blood (139 patients, 63.5%), followed by central blood (24 patients, 11%). Other locations included venipuncture (48 patients, 21.9%) and cerebrospinal fluid (three patients, 1.4%). The results highlight the clinical significance of S. capitis as a major contributor to sepsis, especially in male patients, and emphasize the need for appropriate antibiotic selection for effective treatment. Furthermore, this study raises concerns about the high rates of methicillin resistance observed in S. capitis isolates, emphasizing the urgency in tackling antibiotic resistance and promoting judicious antibiotic prescription practices. Moreover, the identification of a decreased susceptibility to vancomycin as a potential explanation for its reduced effectiveness in treating S. capitis infections adds a crucial aspect to the discussion of treatment options and underscores the need for alternative therapeutic strategies.

Keywords

Coagulase-negative Staphylococci, Prevalence, Multidrug-resistant Staphylococcus capitis, Hospital-acquired Bacteremia

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.