ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Prashanth K. Guddeti , Harshada Shah, Ramanath Karicheri and Luxmi Singh
Department of Microbiology, Index Medical College, Hospital & Research Centre, Malwanchal University, Indore, Madhya Pradesh, India.
Article Number: 8568 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(3):1435-1443. https://doi.org/10.22207/JPAM.17.3.03
Received: 13 March 2023 | Accepted: 06 June 2023 | Published online: 06 July 2023
Issue online: September 2023
Abstract

Acinetobacter baumannii (A. baumannii) is a remarkable opportunistic pathogen responsible for a great proportion of hospital-associated infections and the high prevalence of resistance towards many classes of antibiotics makes the treatment challenging. The present cross-sectional study was conducted in the Department of Microbiology, IMCHRC, Indore. The study was approved by IEC and conducted from October 2019 to September 2021. A total number of 168 Acinetobacter species including 143 A. baumannii were isolated from the various clinical specimens, the majority of the isolates were obtained from the respiratory system (66%), followed by urine, pus/wound swab, blood, fluids and other samples. The majority of the patients who had underlying/diagnosed with a disease such as aspiration pneumonia/pneumonia (35%), cerebrovascular accident/haemorrhagic shock (30.7%), respiratory failure (24%), accelerated HTN/HTN(18%), and less common were septicemia (8.4), acute kidney injury/chronic kidney diseases (7.7%) and trauma/burns (5.5%). The antibiotic susceptibility testing showed higher antibiotic resistance to cefotaxime (94%), ceftazidime (93%), cefepime (92%), imipenem (92%), meropenem (90%) and the resistance was low to doxycycline (39%) Polymyxin B (8%). The association between antibiotic resistance and the clinical profile of patients was found significant (p-value < 0.05). In our study, a remarkably high antibiotic resistance pattern was observed in the classes of antibiotics in A. baumannii isolates, mostly MDR and XDR. To address infection caused by antibiotic-resistant A. baumannii, appropriate antibiotic administration in a clinical setting is essential. Moreover, local and national surveillance data, stringent infection control, and antimicrobial stewardship are required.

Keywords

Acinetobacter baumannii, Antibiogram, Clinical Profile and MDR

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.