ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
P.A. Aboobacker1, Latha Ragunathan1 , Thiyagarajan Sanjeevi2, Aarthi Manoharan2, Aravind C. Sasi1, Vishnu Chandran1, Kavitha Kannaiyan1 and Marcella Sherin Samuel1
1Department of Microbiology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed-to–be-University), Kirumampakkam, Puducherry, India.
2Multi-disciplinary Center for Biomedical Research, Aarupadai Veedu Medical College, Vinayaka Mission’s Research Foundation, Puducherry, India.
Article Number: 8112 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(1):23-34.
Received: 19 September 2022 | Accepted: 17 December 2022 | Published online: 16 January 2023
Issue online: March 2023

Recent instances of novel biological circuits that enable cells to gain biosynthetic skills demonstrate synthetic biology’s therapeutic potential. Synthetic biology is a branch of biology whose primary role is to build completely functional biological systems from the smallest basic elements such as DNA, proteins, and other organic molecules to complex bacteria. This review briefly mentions some novel way of synthetic strategies like bacterial modelling, two-component systems, synthetic peptide, and synthetic flavonoids used for targeting biofilm and drug-stable microbial communities. Bacterial modelling was mainly done in Escherichia coli and Mycoplasma using different strategies like introducing quorum sensing devices and CRISPR-mediated editing. Synthetic peptides are also one of the extensively studied ongoing areas which are produced from natural peptides taking as a template and altering amino acid position. Flavonoids are produced by two-step reaction and molecular hybridization methods. This kind of synthetic approach reported significant biofilm dispersion and lethal effects on clinically relevant bacteria like Pseudomonas aeruginosa, Staphylococcus aureus, E. coli, Acinetobacter baumannii, and Streptococcus species and Klebsiella pneumonia.


Synthetic Peptides, Bacterial Modelling, Engineered Phage, Modified Flavonoids, Bacterial Two-component System

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.