A zoonotic orthopoxvirus known as monkeypox inadvertently produces a smallpox-like illness in humans but with far fewer fatalities. This infection is indigenous to most parts of the African continent, with outbreaks throughout the Western World linked to the exotic animal trade and travel abroad, making it therapeutically significant. Vaccinating against smallpox had historically resulted in coincidental immunization against monkeypox, but the eradication of smallpox and the consequent absence of vaccination has allowed monkeypox to develop prognostic significance. In this article, we discuss our interdisciplinary group’s involvement in patient care and epidemic prevention along with a study of the assessment and treatment of monkeypox, and we provide an overview of the outbreak, describe the most frequent effects of monkeypox, and the healthcare professional’s role in preventing infection and reducing fatalities from monkeypox.