ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Swathi Jonnalagadda1, Y. Prathyusha2, V. Selva Kumar3 and Y. Aparna1
1Department of Microbiology, Bhavan’s Vivekananda College of Science, Humanities and Commerce, Sainikpuri, Secunderabad, Telangana, India.
2Department of Biochemistry, St. Marys College, Yousufguda, Hyderabad, Telangana, India.
3Department of Mathematics and Statistics, Bhavan’s Vivekananda College of Science, Humanities and Commerce, Sainikpuri, Secunderabad, Telangana, India.
Article Number: 7776 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(4):2337-2351.
Received: 24 April 2022 | Accepted: 10 October 2022 | Published online: 14 November 2022
Issue online: December 2022

Corona disease outbreak occurred in 2019 from Wuhan, China and the virus was identified to be a member of the Coronaviridae family. The disease was named as COVID-19 by WHO. It started as an epidemic and later turned into pandemic affecting world wide. The present study was aimed to conduct a systematic review on most prevalent symptoms associated with COVID-19 and to perform a Meta analysis on Comorbidities associated with COVID-19 and assess its severity in underlying conditions. A literature search was conducted using search engines like Pubmed, Web of Science, Elsevier COVID-19 and LitCovid databases between January 2020 and August 2020. Forest plot analysis was done using Random effects model to estimate odds ratio and 95% confidence interval estimate. 83 papers with a sample size of 19,454 were analysed statistically after adopting inclusion and exclusion criteria. Our results showed the most prevalent symptoms to be Cough, fever, dyspnoea and myalgia in interval plot analysis. When assessed for comorbidities, Hypertension (27.02%), Diabetes (16.61%), Cardiovascular disease (12.75%) and Chronic pulmonary obstructive diseases(19.9%) are found to be the most risk factors in comparison with others. However, a finer experimental research needs to be confirmed with the findings.


COVID-19, Systematic Review, Meta Analysis, Comorbidities, Symptoms

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© The Author(s) 2022. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.