ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Lidia Kamal Al-Halaseh1 , Mais A. Sweiss2, Reem A. Issa3, Rehan AlKassasbeh4, Manal Ahmad Abbas3,5, Nariman A. Al-Jawabri1, Maha Nour Abu Hajleh6 and Ali Mahmoud Al-Samydai3
1Department of Pharmaceutical Chemistry, Faulty of Pharmacy, Mutah University, Zip code (61710), Al-Karak, Jordan.
2Department of Biotechnology, Faculty of Agricultural Technology, Al-Balqa Applied University, P. O. Box 206, Al-Salt, 19117, Jordan.
3Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Zipcode (19328), Amman, Jordan.
4Department of Pharmaceutical Sciences, Faulty of Pharmacy, Mutah University, Zip code (61710), Al-Karak, Jordan.
5Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.
6Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Science, Al-Ahliyya Amman University, Zipcode (19328), Amman, Jordan.
Article Number: 8142 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(4):2775-2782. https://doi.org/10.22207/JPAM.16.4.49
Received: 03 October 2022 | Accepted: 02 November 2022 | Published online: 14 November 2022
Issue online: December 2022
Abstract

Nephropathy is a global health issue that affects more than 20% of the adult population. Nephropathy is expected to be the fifth leading cause of death worldwide over the coming two decades. The introduction of green microalgae in nutrition and therapeutics for their biological activities is increasing. The current study examined the effect of Chlorella sorokiniana on renal health after inducing nephrotoxicity in mice. Preliminary screening of the algal aqueous extract revealed the presence of soluble polyphenols and triterpenoids. Successive intraperitoneal doses of gentamicin were administered to mice to induce nephrotoxicity. Concurrent intraperitoneal doses of the algal extract were administered to the infected mice to evaluate their nephroprotective activity. Two different concentrations of the treatment agent were administered in successive doses to two groups of mice. The tested concentrations were 150 and 300 mg/kg of mouse weight, respectively. The other two groups were either left untreated (normal control) or treated only with antibiotics (negative control). Creatinine, urea, and uric acid levels were analyzed in both serum and urine samples to evaluate the renal health of each animal group. Histochemical examination of the renal tissues was performed to assess the damage and improvement status. In vivo studies revealed a promising and significant nephroprotective activity of C. sorokiniana.

Keywords

Microalgae, Nephroprotective, Natural Products, Traditional Medicine, Renal Impairment, Chlorella sorokiniana

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© The Author(s) 2022. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.