ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Balamurali Venkatesan1, Leela Kakithakara Vajravelu1, Sujith Ravi1 , Jayaprakash Thulukanam1 and Om Lokesh Muthamilan2
1Department of Microbiology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, India.
2Department of Microbiology, Kasturba Medical College, 203, Light House Hill Road, Hampankatta, Mangalore, India.
Article Number: 7787 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(4):2324-2336. https://doi.org/10.22207/JPAM.16.4.38
Received: 24 April 2022 | Accepted: 06 September 2022 | Published online: 07 November 2022
Issue online: December 2022
Abstract

Severe Acute Respiratory Syndrome Corona Virus-2 infection is a universal threat in recent days, hence early diagnosis and treatment play a pivotal role in controlling the spread thereby preventing them to become endemic. A newer promising approach by Nanotechnology plays an essential role in targeting the specific pathogens for therapeutic and diagnosis of Viral infection. Certain Nano platforms like Microneedle array delivered Virus S1 subunit vaccines, spike protein nanoparticles, Lumazine synthase Nanoparticles, Silver Nanoparticles, Self-Assembling Protein Nanoparticles against Viral therapy are the upcoming applications as a therapeutic approach. Nucleic acid amplification techniques and Surface-enhanced Raman Spectroscopy shows a high specificity with the immunoassay strategy. In recent days, Colloidal Gold – Nanoparticles and silicon nanoparticles have been widely used as a point of care for quick detection of IgG and IgM antibodies obtained from the virus as a diagnostic approach. Additionally, the Nanoparticles serve as a significant improvement in Personal Protective Equipment and protect against exposure to the virus. As a result of repurposing as well as for the development of the drug, apparently, Nanoparticles themselves and their concomitant therapy or their carriers will be advantageous in making a therapeutic and diagnostic approach against Severe Acute Respiratory Syndrome Corona Virus-2 infections.

Keywords

Severe Acute Respiratory Syndrome Corona Virus-2, Nanotechnology, Nano-particles, Therapeutic and Diagnostic Approaches, Immunoassay Strategies

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