ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Satish Chandel1, Anuradha Dubey2, Parag Sharma1 and Ramesh Agrawal3
1Department of Pharmacology, N.S.C. Govt. Medical College, Khandwa – 450 001, Madhya Pradesh, India.
2Department of Pharmacology, LNMC, Bhopal – 462 042, Madhya Pradesh, India.
3Department of Microbiology, N.S.C. Govt. Medical College, Khandwa – 450 001, Madhya Pradesh, India.
Article Number: 7801 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(3):2117-2122.
Received: 28 April 2022 | Accepted: 13 July 2022 | Published online: 30 August 2022
Issue online: September 2022

The gradual rise of multidrug resistant micro-organisms is a national concern for all health care providers. Linezolid belongs to the oxazolidinone class of antimicrobials. it is a “last resort” used for the management of gram positive bacterial infections. Developing linezolid resistance creates a great challenge for treating bacterial infections. The objective of the current study is to determine the microbial profile and linezolid resistance in gram positive cocci isolated from blood stream infections. 1855 blood samples were analysed for microbial profile and antimicrobial sensitivity testing in our tertiary care centre over a 6 month period. In using Kirby-Bauer’s disk diffusion method for antimicrobial susceptibility testing, linezolid resistance was detected according to CLSI guidelines. Out of 1855 blood culture samples, 732 (39.4%) were identified to be culture positive. Amongst culture positive isolates mostly (83.3%) gram negative bacteria were isolated, and 16.7% were Gram positive bacterial isolates. Klebsiella species were the most prevalent among gram negative isolates. The linezolid resistance pattern was coagulase negative staph (CONS) was 25%, staphylococcus was 24% and streptococcus was 20%. This study reveals significant linezolid resistance in gram positive bacteria isolated from blood culture. The emergence of linezolid resistance is a major issue for clinicians treating the infection and it will require prompt monitoring of antibiotic policy and antimicrobial stewardship programs.


Blood Stream Infections, Blood Culture, Bacterial Isolates, Linezolid Resistance

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© The Author(s) 2022. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.