ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Ebtehal Alqurashi1,2,3 , Khaled Elbanna1,2,4, Iqbal Ahmad5 and Hussein H. Abulreesh1,2
1Department of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
2Research Laboratories Unit, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
3Al Hada Armed Forces Hospital, Ministry of Defense, Taif, Saudi Arabia.
4Department of Agricultural Microbiology, Faculty of Agriculture, Fayoum University, Fayoum, Egypt.
5Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, 202 002, Uttar Pradesh, India.
Article Number: 7897 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(3):1550-1561. https://doi.org/10.22207/JPAM.16.3.59
Received: 10 June 2022 | Accepted: 25 July 2022 | Published online: 24 August 2022
Issue online: September 2022
Abstract

Proteus mirabilis is a specific opportunistic pathogen of many infections including urinary tract infections (UTIs). Risk factors are linked with the acquisition of multidrug-resistant (MDR) to 3 or more classes of antimicrobials) strains. The resistance in extended-spectrum alpha-lactamase is rare, but the rising resistance in extended-spectrum beta-lactamase (ESBL) producing strains is a matter of concern. β-lactamases and antibiotic modifying enzymes mainly constitute the ESBLs resistance mechanism by hydrolyzing the antibiotics. Mutation or Porin loss could lead to the reduced permeability of antibiotics, enhanced efflux pump activity hindering the antibiotic access to the target site, antibiotic failure to bind at the target site because of the target modification, and lipopolysaccharide mutation causing the resistance against polymyxin antibiotics. This review aimed to explore various antimicrobial resistance mechanisms in Proteus mirabilis and their impact on public health status.

Keywords

Proteus mirabilis, Antibiotic Resistance, Beta-lactams, Cephalosporins, Fluoroquinolones, Tetracyclines, Public Health

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